徐恒 特别研究员
研究机构: 交叉科学研究所
研究领域: 生物物理学、定量生物学
办公地点: 理科楼5号楼317
办公电话: 86-21-54742961
电子邮箱: heng_xu@sjtu.edu.cn
研究方向: 1.基因调控动力学;2.单细胞、单分子荧光显微测量技术;3.神经系统发育。
简历:

徐恒,特别研究员,博士生导师。2003年毕业于南京大学匡亚明学院物理专业,获得理学学士学位;2010年毕业于美国布朗大学,获得物理学博士学位;同年进入美国贝勒医学院从事博士后研究工作。2017年加入上海交通大学物理与天文学院。

长期从事生物物理学和定量生物学方面的研究工作,致力于开发单细胞、单分子尺度的定量测量方法和理论模型以理解各种生命过程背后的定量规律。在Science, Nature Methods, Physical Review Letters等顶尖学术期刊上发表多篇论文,并获得2014年度美国Burroughs Wellcome基金会Career Awards at the Scientific Interface。目前的研究主要集中在:(1)基因调控动力学过程的定量测量和理论表征,(2)单细胞、单分子荧光显微测量技术的开发和应用。

主要著作:
  1. Heng Xu, Samuel O. Skinner, Anna M. Sokac, Ido Golding, “Stochastic Kinetics of Nascent RNA”, Physical Review Letters, 117, 128101 (2016).
  2. Leonardo A. Sepúlveda, Heng Xu, Jing Zhang, Mengyu Wang, Ido Golding, “Measurement of Gene Regulation in Individual Cells Reveals Rapid Switching Between Promoter States”, Science, 351(6278), 1218 (2016).
  3. Samuel O. Skinner, Heng Xu, Sonal N. Jaiswal, Pablo R. Freire, Thomas P. Zwaka, Ido Golding, “Single-cell analysis of transcription kinetics across the cell cycle”, Elife, 5, e12175 (2016).
  4. Heng Xu, Leonardo A. Sepúlveda, Lauren Figard, Anna M. Sokac, Ido Golding, “Combining protein and mRNA quantification to decipher transcriptional regulation”, Nature Methods, 12(8), 739 (2015).
  5. Arseny S. Khakhalin, David Koren, Jenny Gu, Heng Xu, Carlos D. Aizenman, “Excitation and inhibition in recurrent networks mediate collision avoidance in Xenopus tadpoles”, European Journal of Neuroscience, 40(6), 2948 (2014).
  6. Lauren Figard, Heng Xu, Hernan Garcia, Ido Golding, Anna M. Sokac, “The plasma membrane flattens out to fuel cell surface growth during Drosophila cellularization”, Developmental Cell 27(6), 648 (2013).
  7. Samuel O. Skinner, Leonardo A. Sepúlveda, Heng Xu, Ido Golding, “Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization”, Nature Protocols. 8(6), 1100 (2013).
  8. Heng Xu, Arseny S. Khakhalin, Arto V. Nurmikko, Carlos D. Aizenman, “Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system”, Journal of Neuroscience. 31(22), 8025 (2011).
  9. Wei Dong, Ryan H. Lee, Heng Xu, Shelley Yang, Kara G. Pratt, Vania Cao, Yoon-Kyu Song, Arto V. Nurmikko, Carlos D. Aizenman, "Visual avoidance in Xenopus tadpoles is correlated with the maturation of visual responses in the optic tectum", Journal of Neurophysiology. 101(2), 803 (2009).
  10. Heng Xu, Jiayi Zhang, Kristina M. Davitt, Yoon-Kyu Song, Arto V. Nurmikko, "Application of blue-green and ultraviolet micro-LEDs to biological imaging and detection", Journal of Physics D 41(9), 094013 (2008).
  11. Heng Xu, Kristina M. Davitt, Wei Dong, Yoon-Kyu Song, William R. Patterson III, Carlos D. Aizenman, Arto V. Nurmikko, "Combining multicore imaging fiber with matrix addressable blue/green LED arrays for spatiotemporal photonic excitation at cellular level", IEEE Journal of Selected Topics in Quantum Electronics 14(1), 167 (2008).
  12. Heng Xu, Kristina M. Davitt, Wei Dong, Yoon-Kyu Song, William R. Patterson III, Arto V. Nurmikko, Carlos D. Aizenman, “Integration of a matrix addressable blue/green LED array with multicore imaging fiber for spatiotemporal excitation in endoscopic biomedical applications”. Phys. Stat. Sol. c 5(6) 2299 (2008).
  13. Sowmya Venkataramani, Kristina M. Davitt, Heng Xu, Jiayi Zhang, Yoon-Kyu Song, Barry W. Connors, Arto V. Nurmikko, “Semiconductor ultra-violet light-emitting diodes for flash photolysis”, Journal of Neuroscience Methods 160(1), 5 (2007).
  14. Jiayi Zhang, Sowmya Venkataramani, Heng Xu, Yoon-Kyu Song, Hyun-Kon Song, G. Tayhas. R. Palmore, Justin Fallon, Arto V. Nurmikko, “Combined topographical and chemical micropatterns for templating neuronal networks”, Biomaterials 27(33), 5734 (2006).
  15.  Sowmya Venkataramani, Kristina M. Davitt, Jiayi Zhang, Heng Xu, Yoon-Kyu Song, Barry W. Connors, Arto V. Nurmikko, “Compact semiconductor light-emitting diodes for dynamic imaging of neuronal circuitry”, IEEE Journal of Selected Topics in Quantum Electronics 11(4), 785 (2005).